Gastroesophageal reflux disease (GERD) is becoming more common. The symptoms include heartburn, return of stomach contents up the esophagus, trouble swallowing, coughing, hoarseness and/or chest pain. With GERD, gastric contents, including stomach acid (hydrochloric acid,) are forced up into the esophagus.
The most common GERD treatment at this time is with proton pump inhibitors (PPI) such as the drug omeprazole. PPI medications reduce acid production. PPI drugs do have side effects; but, there is concern that chronic PPI medications can be carcinogenic.
This study was done to see if a combination of melatonin (6 mg.), l-tryptophan (200 mg.), vitamin B-6 (25 mg.), folic acid (10 mg.), vitamin B-12 (50 ug), methionine (100 mg.) and betaine (100 mg.) can relieve GERD, compared to omeprazole. One dose was given, daily. Melatonin inhibits gastric acid secretion and nitric oxide production. Nitric acid plays a role in relaxation of the lower esophageal sphincter muscle. Some of the other supplements are anti-inflammatory and relieve pain.
The study was a single blind randomized study. A total of 351 patients were studied. Half of them received the supplements as listed above and half received 20 mg omeprazole. All patients kept a diary of their symptoms. All of the patients on the compound had complete relief of their symptoms in 40 days. Only 2/3rd of the patients on omeprazole had relief of their symptoms in 40 days. The differences between the two groups were statistically significant.
CONCLUSION: A combination of supplements, with tryptophan, methionine and melatonin, was 100% effective in relieving GERD.
PMID: 16948779.
Summary #295.