Carnosine is a dipeptide, consisting of two amino acids, beta-alanine and l-histidine. It’s function in exercise includes muscle contractility, calcium sensitivity in muscles, and pH balance. It may be the major intracellular buffer.

The ability to physically produce carnosine depends on a good supply of beta-alanine, which is increasingly being used by people in athletics to improve performance. The authors did a review of the literature on athletic performance and beta-alanine supplementation. The review attempted to establish a useful dosage which would minimize the major side effect, paresthesia*.

CONCLUSION: Carnosine is a dipeptide used to enhance athletic performance, while minimizing the side effect of tingling. Carnosine is the major intracellular chelator.

NOTE: *Paresthesia refers to a tingling, burning, or other similar sensation of the skin without apparent physical effect.

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PMID: 25561107.

Summary #715.